Association of follow-up infarct volume with functional outcome in acute ischemic stroke: A pooled analysis of seven randomized trials

AMM Boers; IGH Jansen; LFM Beenen; TG Devlin; LS Roman; JH Heo; M Ribo; S Brown; MA Almekhlafi; DS Liebeskind; J Teitelbaum; HF Lingsma; WH Van Zwam; P Cuadras; RDM De Rochemont; M Beaumont; MM Brown; AJ Yoo; RJ Van Oostenbrugge; BK Menon; GA Donnan; JL Mas; YBWEM Roos; C Oppenheim; A Van Der Lugt; RJ Dowling; MD Hill; A Davalos; T Moulin; N Agrinier; AM Demchuk; DK Lopes; LA Rodriguez; DWJ Dippel; BCV Campbell; PJ Mitchell; FS Al-Ajlan; TG Jovin; J Madigan; GW Albers; S Soize; F Guillemin; VK Reddy; S Bracard; J Blasco; KW Muir; RG Nogueira; PM White; M Goyal; SM Davis; HA Marquering; CBLM Majoie

Journal article

Association of follow-up infarct volume with functional outcome in acute ischemic stroke: A pooled analysis of seven randomized trials

AMM Boers, IGH Jansen, LFM Beenen, TG Devlin, LS Roman, JH Heo, M Ribo, S Brown, MA Almekhlafi, DS Liebeskind, J Teitelbaum, HF Lingsma, WH Van Zwam, P Cuadras, RDM De Rochemont, M Beaumont, MM Brown, AJ Yoo, RJ Van Oostenbrugge, BK Menon Show all

Journal of Neurointerventional Surgery | Published : 2018

DOI: 10.1136/neurintsurg-2017-013724

Abstract

Background Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement. Objective To examine the association of FIV with 90- day modified Rankin Scale (MRS) score and investigate its dependency on acquisition time and modality. Methods Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI. Infarct location was defined as laterality and involvement of the Alberta Stroke Program Early CT Score regions. Relative quality and strength of multivariable regression models of the association between FIV and functi..

View full abstract